Israel launched airstrikes across the Gaza Strip early Tuesday, killing at least 404 Palestinians, including women and children, according to hospital officials.

The surprise bombardment shattered a ceasefire in place since January and threatened to fully reignite the 17-month-old war.

Prime Minister Benjamin Netanyahu ordered the strikes after Hamas refused Israeli demands to change the ceasefire agreement.

Officials said the operation was open-ended and was expected to expand. The White House said it had been consulted and voiced support for Israel's actions.

The Israeli military ordered people to evacuate eastern Gaza, including much of the northern town of Beit Hanoun and other communities further south, and head toward the center of the territory, indicating that Israel could soon launch renewed ground operations.

“Israel will, from now on, act against Hamas with increasing military strength,” Netanyahu’s office said.

The surprise attack shattered a period of relative calm during the Muslim holy month of Ramadan and raised the prospect of a full return to fighting in a 17-month war that has killed tens of thousands of Palestinians and caused widespread destruction across Gaza.

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